Drug Standards
Selleck Chemical LLC Flurbiprofen Axetil
Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase
Medchemexpress LLC Binimetinib | 606143-89-9 | 1 ML
Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor with an IC50 of 12 nM. It demonstrates antiproliferative activity against various human cancer cell lines, including those with KRAS and NRAS mutations, and reduces disease severity in animal models.
- Oral and selective MEK1/2 inhibitor.
- Potently inhibits MEK with an IC50 of 12 nM.
- Blocks basal ERK phosphorylation in HRAS mutant cell lines.
- Exhibits antiproliferative activity against various KRAS and NRAS mutant human cancer cell lines.
- Reduces disease severity in animal models.
- Demonstrates enhanced efficacy when combined with other agents in animal models.
- Shows significant tumor growth reduction when combined with BEZ235.
Med Vet International Geri-Care Loratadine Allergy Relief, 788-09-GCP, 90/Bottle
Antihistamine tablets alleviate itchy, watery eyes, itchy nose and throat, sneezing and runny nose; provides relief so users feel more comfortable. Antihistamine is a nondrowsy type. There are 10 milligrams of loratadine per tablet. Compare to the active ingredient in Claritin – a registered trademark of Bayer Consumer Health.
Medchemexpress LLC Benazepril | 86541-75-5 | 99.9% | C24H28N2O5 | 100 MG
Benazepril is an orally active angiotensin-converting enzyme (ACE) inhibitor that effectively reduces angiotensin-II production. It inhibits oxidative stress and apoptosis through the PI3K/Akt signaling pathway, making it valuable in the study of hypertension, heart failure, and diabetic nephropathy. It has been shown to improve diabetic nephropathy and decrease proteinuria.
- Orally active angiotensin-converting enzyme (ACE) inhibitor
- Reduces angiotensin-II production
- Inhibits oxidative stress and apoptosis via the PI3K/Akt signaling pathway
- Improves diabetic nephropathy
- Decreases proteinuria
- Used in the study of hypertension, heart failure, and diabetic nephropathy
Medchemexpress LLC Imatinib-d3 hydrochloride | 1134803-18-1 | C29H28D3N7O | 1 MG
Imatinib-d3 hydrochloride is a deuterium labeled form of Imatinib, an orally bioavailable tyrosine kinase inhibitor. It selectively inhibits BCR/ABL, v-Abl, PDGFR, and c-kit kinase activity by binding near the ATP binding site. The compound also inhibits SARS-CoV and MERS-CoV.
- Used as a tracer for quantitation during drug development
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Selectively inhibits BCR/ABL, v-Abl, PDGFR, and c-kit kinase activity
- Inhibits SARS-CoV and MERS-CoV
- Deuterium labeling can affect pharmacokinetic and metabolic profiles of drugs
Selleck Chemical LLC Canagliflozin 5mg 842133-18-0 TA 7284, JNJ 28431754
Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Duvelisib (IPI-145) 10mM/1mL 1201438-56-3 INK1197
Duvelisib (IPI-145, INK1197) is a novel and selective PI3K ?/? inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K ?/? than other protein kinases. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Sofosbuvir impurity 1 | C₁₈H₁₇F₅NO₅P | 5 MG
Sofosbuvir impurity 1 is an impurity of Sofosbuvir, primarily intended for scientific research or drug declaration purposes. This product is not for personal use.
- Molecular weight: 453.30
- Appearance: Solid
- Color: White to off-white
- Shipping conditions: Room temperature in continental US (may vary elsewhere)
- Storage: Three years at room temperature; two years at -80°C in solvent, one year at -20°C in solvent
Medchemexpress LLC Nintedanib impurity 5 | 676326-36-6 | C12H11NO4 | 100 MG
Nintedanib impurity 5 is an impurity of Nintedanib (HY-50904), a target drug intermediate. This compound is suitable for various laboratory applications.
- Stable at room temperature for 3 years
- Stable in solvent at -80°C for 2 years
- Stable in solvent at -20°C for 1 year
Medchemexpress LLC Suvorexant impurity 1 | 2941-79-9 | ≥98.0% | C16H14O4 | 100 MG
Suvorexant impurity 1 is an impurity of Suvorexant, presented as an off-white to brown solid.
- Research reagent
- Not for medical, clinical diagnostic, or food use in humans or animals
- Powder storage: -20°C for 3 years or 4°C for 2 years
- In-solvent storage: -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC Amoxicillin 26787-78-0 5g
Amoxicillin (26787-78-0) is a small-molecule inhibitor targeting bacterial penicillin-binding proteins (PBPs) It is designed to disrupt bacterial cell wall biosynthesis thereby impairing peptidoglycan cross-linking and compromising cell wall integrity Amoxicillin exerts its biological activity primarily through inhibition of PBPs interfering with the processes critical to bacterial cell wall formation In in vitro studies Amoxicillin demonstrates inhibitory activity with IC50 values ranging from 0 1 to 5 g/mL depending on experimental conditions and organism susceptibility Based on these pharmacological properties Amoxicillin holds research potential in studies of bacterial infection mechanisms antimicrobial responses and resistance development
Selleck Chemical LLC Salinomycin
Salinomycin traditionally used as an anti-coccidial drug has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects
Sigma Aldrich Fine Chemicals Biosciences o-Flutamide United States Pharmacopeia (USP) Reference Standard | 151262-93-0 | 50MG
o-Flutamide United States Pharmacopeia (USP) Reference Standard | Mol Wt: 276.21 | 151262-93-0 | 50MG
Sigma Aldrich Fine Chemicals Biosciences Montelukast sodium European Pharmacopoeia (EP) Reference Standard | 151767-02-1 |
Montelukast sodium European Pharmacopoeia (EP) Reference Standard | Mol Wt: 608.17 | 151767-02-1 |
Selleck Chemical LLC Encorafenib (LGX818) 1mg 1269440-17-6
Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.